![]() Using the Berlin definition, acute respiratory distress syndrome (ARDS) was diagnosed in 31% of the patients with a hospital mortality of 52%. ICU and hospital mortality rates were 34% and 42%. The main reasons for ventilatory support were pneumonia (27%), neurologic disorders (19%) and non-pulmonary sepsis (12%). Failure with subsequent intubation occurred in 54% of NIV patients. Results Invasive MV and NIV were used as initial ventilatory support in 622 (80%) and 151 (20%) patients. Multivariate analysis was used to identifiy variables associated with hospital mortality and NIV failure. Causes of ventilatory support, prior chronic health status and physiological data were assessed. Methods In a multicenter, prospective, cohort study, a total of 773 adult patients admitted to 45 ICUs over a two-month period requiring invasive ventilation or NIV for more than 24 hours were evaluated. We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality and failure of NIV in patients requiring ventilatory support in Brazilian intensive care units (ICU). ![]() ![]() Moreover, most epidemiological studies on ventilatory support were carried out before significant developments, such as lung protective ventilation or broader application of non-invasive ventilation (NIV). ![]() Introduction Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study ![]()
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